氨基胍、氯丙嗪和NSD - 1055对沙伊大鼠胃分泌及溃疡形成的影响
Effect of aminoguanidine, chlorpromazine and NSD-1055 on gastric secretion and ulceration in the Shay rat.
作者信息
Radwan A G, West G B
出版信息
Br J Pharmacol. 1971 Jan;41(1):167-9. doi: 10.1111/j.1476-5381.1971.tb09946.x.
Abstract
Both chlorpromazine and NSD-1055 (a non-steroidal anti-inflammatory drug) markedly lower the volume and acidity of gastric contents of rats subjected to pyloric ligation (Shay technique) and reduce the degree of ulceration in the stomach. On the other hand, aminoguanidine (an inhibitor of histaminase) has no effect on acid secretion or ulceration in these animals.
摘要
氯丙嗪和NSD - 1055（一种非甾体抗炎药）均可显著降低幽门结扎（谢伊技术）大鼠的胃内容物体积和酸度，并减轻胃的溃疡程度。另一方面，氨基胍（一种组胺酶抑制剂）对这些动物的胃酸分泌或溃疡没有影响。
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