Sargent E N, Boswell W, Hubsher J
AJR Am J Roentgenol. 1978 Jun;130(6):1051-5. doi: 10.2214/ajr.130.6.1051.
The effect of intravenous and intramuscular administration of ceruletide on gallbladder contraction was investigated in 67 normal volunteers and patients. Of the 45 normal volunteers, 33 received the drug intravenously and 12 intramuscularly in graded ascending doses. By either means of injection, ceruletide produced a substantial contraction of the gallbladder with a measurable reduction in gallbladder area. Based on findings in these groups, the 22 patients requiring oral cholecystography for clinical evaluation received 0.3 microgram/kg intramuscularly. The intramuscular administration of synthetic ceruletide after oral cholecystography, in a dose of 0.o microgram/kg, afforded a safe and effective means of gallbladder contraction, with resultant cystic and common bile duct visualization. Side effects occurred less frequently when the drug was administered intramuscularly and were minimal and self-limiting. Peak contraction (40% or greater reduction in size) occurred as early as 5-15 min after after intramuscular injection and in most instances within 30 min.
在67名正常志愿者和患者中研究了静脉注射和肌肉注射雨蛙肽对胆囊收缩的影响。45名正常志愿者中，33人静脉注射该药物，12人肌肉注射，剂量均为逐步递增。通过任何一种注射方式，雨蛙肽均可使胆囊产生明显收缩，胆囊面积可测量减小。基于这些组的研究结果，22名因临床评估需要进行口服胆囊造影的患者接受了0.3微克/千克的肌肉注射。口服胆囊造影后肌肉注射合成雨蛙肽，剂量为0.0微克/千克，提供了一种安全有效的胆囊收缩方法，可使胆囊和胆总管显影。肌肉注射该药物时副作用发生频率较低，且症状轻微且为自限性。肌肉注射后最早在5 - 15分钟出现最大收缩（尺寸减小40%或更多），大多数情况下在30分钟内出现。
