人体外周循环中的组胺H2受体。
Histamine H2-receptors in the human peripheral circulation.
作者信息
Chipman P, Glover W E
出版信息
Br J Pharmacol. 1976 Apr;56(4):494-6. doi: 10.1111/j.1476-5381.1976.tb07463.x.
Abstract
Histamine (10 mug/min for 3 min) infused into the brachial artery caused an increase in forearm blood flow which was reduced by mepyramine (25 mg). This effect was most marked in the first minute of the infusion. Metiamide (25 mg) had no effect on the dilatation during the infusion but caused a quicker return of flow to the resting level. The response was abolished when both drugs were given in combination. It is concluded that the response is initiated mainly by stimulation of H1-receptors and maintained by H1- and H2-receptors; continued activity of H2-receptors may account for the slow return of flow to the pre-infusional level.
摘要
向肱动脉内注入组胺（10微克/分钟，持续3分钟）可使前臂血流量增加，而甲吡胺（25毫克）可使其降低。这种效应在注入的第一分钟最为明显。甲硫米特（25毫克）在注入期间对血管扩张无影响，但能使血流量更快恢复到静息水平。当两种药物联合使用时，这种反应消失。结论是，该反应主要由H1受体的刺激引发，并由H1和H2受体维持；H2受体的持续活性可能是血流量缓慢恢复到注入前水平的原因。
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