Boyce M J
Klin Wochenschr. 1982 Sep 1;60(17):978-82. doi: 10.1007/BF01716958.
Data from pharmacological studies carried out in healthy subjects using systemic histamine or impromidine and their antagonists are reviewed. Exogenous histamine by rapid injection appears to stimulate only H1-receptors. Chlorpheniramine alone antagonised the responses to histamine. The effects of cardiovascular H2-receptor stimulation are demonstrated best by a sustained and large dose of histamine given by infusion. If it be considered desirable to antagonise all the cardiovascular responses to endogenous histamine, the available pharmacological data in man suggest this would be achieved best by a combination of an H1-and H2-receptor antagonist.
本文综述了在健康受试者中使用全身性组胺或英普咪定及其拮抗剂进行的药理学研究数据。快速注射外源性组胺似乎仅刺激H1受体。单独使用氯苯那敏可拮抗组胺反应。通过持续输注大剂量组胺能最好地证明心血管H2受体刺激的作用。如果认为拮抗内源性组胺的所有心血管反应是可取的，那么人体现有的药理学数据表明，联合使用H1和H2受体拮抗剂能最好地实现这一点。
