Todorov A B, Lenn N J, Gabor A J
Arch Neurol. 1978 Jun;35(6):389-91. doi: 10.1001/archneur.1978.00500300063012.
We describe a patient whose absence seizures increased greatly in number after the addition of ethosuximide to ongoing phenobarbital therapy. This unusual response and review of other cases in the literature suggested the possibility of some as yet underfined interaction between ethosuximide and other anticonvulsant drugs. That a particular subytpe of epilepsy may be worsened by ethosuximide therapy is also considered.
我们描述了一名患者，在其正在进行的苯巴比妥治疗中加用乙琥胺后，失神发作的次数大幅增加。这种不寻常的反应以及对文献中其他病例的回顾提示，乙琥胺与其他抗惊厥药物之间可能存在某种尚未明确的相互作用。还考虑到乙琥胺治疗可能会使某一特定亚型的癫痫恶化。
