Kalff M W, Hijmans W
Clin Exp Immunol. 1969 Nov;5(5):479-98.
Serum electrophoresis and quantitative determination of serum immunoglobulin levels were performed in 353 relatives of twenty-three patients with macroglobulinaemia. The immunoglobulin levels in the relatives were compared with the levels found in a random sample of the total population of a rural district; the validity of this comparison is discussed. The number of abnormalities in the electropherograms is discussed in relation to the data in the literature. Only the number of abnormalities, both quantitative and qualitative, found in the IgM class was higher than would be expected in the general population, if only chance were involved. Abnormalities also occurred in the IgG and IgA classes, but their number is not higher than expected, thus indicating that they are not associated with the disease in the propositus. Several possible explanations for the concentration of IgM abnormalities in families of patients with macroglobulinaemia are discussed.
对23例巨球蛋白血症患者的353名亲属进行了血清电泳和血清免疫球蛋白水平的定量测定。将亲属的免疫球蛋白水平与从一个农村地区总人口中随机抽取的样本所测得的水平进行了比较，并讨论了这种比较的有效性。结合文献数据讨论了电泳图谱中的异常数量。如果仅考虑偶然因素，只有在IgM类别中发现的定量和定性异常数量高于一般人群的预期。在IgG和IgA类别中也出现了异常，但其数量并不高于预期，因此表明它们与先证者的疾病无关。讨论了巨球蛋白血症患者家族中IgM异常集中的几种可能解释。
