Laxdal O E, Merida J, Jones R H
Can Med Assoc J. 1970 Feb 14;102(3):263-8.
Results of the use of ampicillin, penicillin G and symptomatic therapy in the treatment of acute otitis media in 142 children were compared. Antibiotic therapy conveyed significant benefit. No major differences were observed between penicillin and ampicillin, except in the age group under 3 years where ampicillin was associated with the best results. Ampicillin appears to be the drug of choice. Its superiority over symptomatic therapy was statistically significant. Long-term sequelae were not observed in any of the three treatment groups. The relative merits of erythromycin and ampicillin require further study.
对142名儿童使用氨苄西林、青霉素G及对症治疗急性中耳炎的结果进行了比较。抗生素治疗带来了显著益处。除了在3岁以下年龄组中氨苄西林效果最佳外，青霉素和氨苄西林之间未观察到重大差异。氨苄西林似乎是首选药物。其相对于对症治疗的优越性具有统计学意义。三个治疗组中均未观察到长期后遗症。红霉素和氨苄西林的相对优点需要进一步研究。
