Johansson S G, Bennich H, Berg T, Högman C
Clin Exp Immunol. 1970 Jan;6(1):43-7.
Diagnosis of atopic diseases can sometimes present difficulties. IgE estimation in serum can obviously be of value in these cases. However, on evaluating the results consideration must be taken of several different factors which may be of importance with regard to the levels of this immunoglobulin. Some of these are discussed here. Patients with asthma and atopic eczema have raised IgE levels more often than patients with hay fever. In the latter cases a significant increase in the IgE level is found during the pollination season. Dust and mould seem to be weak allergens which seldom give rise to elevated IgE levels. Specific hyposensitizaion significantly increased the IgE levels during the first 3 weeks of treatment. Steroids, cytostatics and disodium cromoglycate do not seem to influence the IgE concentrations nor do bacterial or viral infections. Markedly increased IgE concentrations were found in patients with parasitic infestations; Ascaris lumbricoides is one of the parasites of current interest.
特应性疾病的诊断有时会存在困难。血清中IgE的测定在这些病例中显然具有重要价值。然而，在评估结果时，必须考虑几个不同的因素，这些因素对于这种免疫球蛋白的水平可能很重要。这里讨论其中一些因素。哮喘和特应性湿疹患者的IgE水平升高比花粉热患者更常见。在后一种情况下，在授粉季节发现IgE水平显著升高。灰尘和霉菌似乎是较弱的过敏原，很少导致IgE水平升高。特异性脱敏治疗在治疗的前3周显著提高了IgE水平。类固醇、细胞抑制剂和色甘酸钠似乎不会影响IgE浓度，细菌或病毒感染也不会。在寄生虫感染患者中发现IgE浓度显著升高；蛔虫是目前备受关注的寄生虫之一。
