Mitchell E B, Askenase P W
Clin Rev Allergy. 1983 Sep;1(3):427-48. doi: 10.1007/BF02991231.
Hypersensitivity reactions containing significant infiltrates of basophils occur in a large proportion of allergic diseases such as contact dermatitis, atopic dermatitis, and allergic rhinitis, and are quite deleterious. However, the potential usefulness of such responses can be recognized in similar reactions in guinea pigs responding to tissue invasion by complex multicellular parasites in which interactions occur between thymic-derived T lymphocytes, antibodies, and basophils in immune resistance responses. Perhaps inappropriate and deleterious allergic responses to pollens, chemicals, and insects is the price that we must pay for the ability to reject complex parasites.
包含大量嗜碱性粒细胞浸润的超敏反应在很大一部分过敏性疾病中都会出现，如接触性皮炎、特应性皮炎和过敏性鼻炎，且危害极大。然而，在豚鼠对复杂多细胞寄生虫组织入侵的类似反应中，可以认识到这种反应的潜在益处，在免疫抵抗反应中，胸腺来源的T淋巴细胞、抗体和嗜碱性粒细胞之间会发生相互作用。也许对花粉、化学物质和昆虫产生不适当且有害的过敏反应，是我们为具备抵御复杂寄生虫的能力而必须付出的代价。
