Keane P E, Kan J P, Sontag N, Benedetti M S
J Pharm Pharmacol. 1979 Nov;31(11):752-4. doi: 10.1111/j.2042-7158.1979.tb13651.x.
Rats were administered toloxatone 100 mg kg-1 p.o., and killed 0.5 to 8 hours later. Toloxatone reversibly inhibited type A MAO, but did not affect the activity of type B MAO in whole brain. Cerebral concentrations of noradrenaline, dopamine and 5-hydroxytryptamine were increased after toloxatone, while their metabolite concentrations were reduced. Synaptosomal uptake processes of these amines were not altered by tolaxatone.
给大鼠口服托洛沙酮100毫克/千克，0.5至8小时后处死。托洛沙酮可逆性抑制全脑中的A型单胺氧化酶，但不影响B型单胺氧化酶的活性。给予托洛沙酮后，脑内去甲肾上腺素、多巴胺和5-羟色胺的浓度升高，而它们的代谢物浓度降低。托洛沙酮未改变这些胺类的突触体摄取过程。
