Nikitina G V
Probl Endokrinol (Mosk). 1979 Jan-Feb;25(1):68-71.
Data of experimental character reflecting the pharmacological activity of 16alpha-methylene derivative of progesterone--melengesterol acetate--are presented. A high progestagenic activity of the preparation was revealed in a series of tests, namely, the appearance of secretory changes in the uterine endometrium of infantile female rabbits and persistence of pregnancy in ovariectomized rabbits. A high contraceptive activity not accompanied by suppression of ovulation was found in administration of the preparation in low doses combined with mestranol.
本文给出了反映孕酮16α-亚甲基衍生物——醋酸甲地孕酮药理活性的实验数据。在一系列试验中发现该制剂具有较高的孕激素活性，即在幼年雌性兔子宫内膜出现分泌性变化以及使去卵巢兔维持妊娠。还发现小剂量该制剂与炔雌醇合用具有高避孕活性且不抑制排卵。
