[6-甲基取代的Δ⁶-孕甾烯与炔雌醇甲醚组合的避孕活性及作用机制]
[Contraceptive activity and mechanism of action of combinations of 6-methyl-substituted D'6-pentaranes and mestranol].
作者信息
Korkhov V V, Nikitina G V, Kamernitskiĭ A V, Kulikova L E, Levina I S
出版信息
Farmakol Toksikol. 1981 Jan-Feb;44(1):95-8.
PMID:7021175
Abstract
It has been shown in experiments on rats, mice and rabbits that 6 alpha-methyl-16 alpha, 17 alpha-cyclohexano-pregna-4-en-3, 20-dion and 6-methyl-16 alpha, 17 alpha-cyclohexano-pregna-4,6-dien-3,20-dion belonging to the series of D'6-pentaranes exhibit high contraceptive activity when combined with mestranol. The contraceptive activity of D'6-pentaranes combined with mestranol arises primarily from their inhibitory effect on luteinizing function of the hypophysis.
摘要
在对大鼠、小鼠和兔子进行的实验中已表明，属于D'6-戊烷系列的6α-甲基-16α,17α-环己烷孕甾-4-烯-3,20-二酮和6-甲基-16α,17α-环己烷孕甾-4,6-二烯-3,20-二酮与炔雌醇甲醚合用时表现出高避孕活性。D'6-戊烷与炔雌醇甲醚合用的避孕活性主要源于它们对垂体促黄体生成功能的抑制作用。
Zotero 插件