Petermann M, Bravo M, Videla L, Ugarte G
Pharmacology. 1979;18(1):42-7. doi: 10.1159/000137228.
Chronic administration of epinephrine to adult male rats resulted in a significant increase in the rate of ethanol elimination, when given alone or together with the beta-adrenergic blocker alprenolol. This effect was observed concomitantly with an increased hepatic oxygen utilization and no changes in mitochondrial respiratory functions. Epinephrine given acutely did not modify the rate of ethanol metabolism. Blood glucose levels were enhanced in these conditions, but were unaffected in rats treated with epinephrine plus alprenolol. These results suggest that chronic epinephrine treatment induces an increased oxidative capacity in the liver characterized by enhanced rates of oxygen uptake and ethanol metabolism, which is not related to its beta-adrenergic actions.
对成年雄性大鼠长期给予肾上腺素，无论单独给药还是与β-肾上腺素能阻滞剂阿普洛尔联合给药，均导致乙醇消除速率显著增加。这一效应与肝脏氧利用率增加同时出现，而线粒体呼吸功能无变化。急性给予肾上腺素并未改变乙醇代谢速率。在这些情况下，血糖水平升高，但肾上腺素加阿普洛尔治疗的大鼠血糖水平未受影响。这些结果表明，长期肾上腺素治疗可诱导肝脏氧化能力增加，其特征为氧摄取和乙醇代谢速率加快，这与其β-肾上腺素能作用无关。
