Newburger J, Wagner J G, Stavchansky S
J Pharmacokinet Biopharm. 1979 Aug;7(4):417-25. doi: 10.1007/BF01062539.
An equation is presented which allows infinity values for biexponential processes to be predicted in the early nonlinear phase when samples are taken at equal time intervals. This equation is independent of the value or ratio of the rate constants involved in the process. However, this method is very sensitive to noise normally associated with urine data.
本文提出了一个方程,当以等时间间隔采集样本时,该方程可用于预测双指数过程在早期非线性阶段的无穷大值。此方程与该过程中速率常数的值或比率无关。然而,该方法对通常与尿液数据相关的噪声非常敏感。