血液灌流期间隔室间速率常数变化对药物清除的影响。
Effect of changes in intercompartment rate constants on drug removal during hemoperfusion.
作者信息
Gibson T P, Atkinson A J
出版信息
J Pharm Sci. 1978 Aug;67(8):1178-9. doi: 10.1002/jps.2600670844.
PMID:671264
Abstract
A computer simulation of the effect of changing intercompartment clearance rates on drug removal during hemoperfusion was undertaken. As intercompartment clearance slowed, the fall in plasma levels increased and postperfusion rebound increased, but the total drug removed decreased.
摘要
进行了一项计算机模拟，研究在血液灌流期间改变隔室间清除率对药物清除的影响。随着隔室间清除减慢，血浆水平下降增加，灌流后反弹增加，但药物总清除量减少。
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