Bonomo L, Tursi A, Trizio D, Gillardi U, Dammacco F
Immunology. 1970 Apr;18(4):557-63.
Complexes of IgG—rheumatoid factor (RF) and IgG—β were demonstrated in the synovial membrane obtained from patients with rheumatoid arthritis (RA) by a mixed immunofluorescence method that shows simultaneously the two components of the complex. IgG—RF was found only in the synovia of cases with circulating RF, while IgG—β deposits could be detected in both seropositive and seronegative cases. These findings are discussed in connection with the pathogenesis of rheumatoid synovitis in the light of the immune complex pathogenetic mechanism.
通过一种能同时显示复合物两种成分的混合免疫荧光法，在类风湿关节炎（RA）患者的滑膜中证实了IgG-类风湿因子（RF）复合物和IgG-β复合物。仅在有循环RF的病例的滑膜中发现了IgG-RF，而在血清阳性和血清阴性病例中均能检测到IgG-β沉积物。根据免疫复合物致病机制，结合类风湿滑膜炎的发病机制对这些发现进行了讨论。
