急性化脓性中耳炎和分泌性中耳炎中耳积液中的溶菌酶活性及免疫球蛋白

Lysozyme activity and immunoglobulins in middle ear effusion fluid in acute purulent otitis media and in otitis media with effusion.

作者信息

Virtanen S, Lahikainen E A

出版信息

Scand J Infect Dis. 1979;11(1):63-7. doi: 10.3109/inf.1979.11.issue-1.10.

DOI:10.3109/inf.1979.11.issue-1.10

PMID:419370

Abstract

147 samples of punctured middle ear effusion fluid from cases of otitis media with effusion and 150 samples from patients with acute purulent otitis media were tested for lysozyme activity. In otitis media with effusion the concentration was 182.0 U/ml, in acute otitis 433.8 U/ml. The lysozyme concentration in otitis media with effusion depended upon the nature of the effusion. Serous fluid showed an activity of 124.8 U/ml and mucoid 311.6 U/ml, respectively. In culture-positive cases of acute otitis media the lysozyme level was 423.4 U/ml. Culture-negative cases showed about the same concentration, 438.3 U/ml. The possible role of lysozyme in defence systems of the middle ear is discussed.

摘要

对147份来自渗出性中耳炎病例的中耳穿刺积液样本以及150份来自急性化脓性中耳炎患者的样本进行了溶菌酶活性检测。在渗出性中耳炎中，浓度为182.0 U/ml，在急性中耳炎中为433.8 U/ml。渗出性中耳炎中的溶菌酶浓度取决于积液的性质。浆液性积液的活性分别为124.8 U/ml，黏液性积液为311.6 U/ml。在急性中耳炎培养阳性的病例中，溶菌酶水平为423.4 U/ml。培养阴性的病例显示出大致相同的浓度，为438.3 U/ml。文中讨论了溶菌酶在中耳防御系统中的可能作用。