秋水仙碱对鸡轴突蛋白运输的影响。
The effect of colchicine on the transport of axonal protein in the chicken.
作者信息
James K A, Bray J J, Morgan I G, Austin L
出版信息
Biochem J. 1970 May;117(4):767-71. doi: 10.1042/bj1170767.
Abstract
- Small doses (1-10mug) of colchicine injected into the ventral horn of the spinal cord of the chicken caused paralysis in the legs. 2. Colchicine had no effect on the incorporation of leucine into proteins of the spinal cord but markedly decreased the total amount of protein flowing into the axons of the sciatic nerve. 3. This axonal flow of protein proceeded at two rates: a high rate (300mm/day) and a low rate (2mm/day). Although both groups of proteins were affected, the slow transport of protein was more profoundly blocked by colchicine. 4. The results suggest that axonal flow is dependent on the neurotubular system in the axon.
摘要
- 向鸡脊髓腹角注射小剂量（1 - 10微克）秋水仙碱会导致腿部麻痹。2. 秋水仙碱对亮氨酸掺入脊髓蛋白质的过程没有影响，但显著降低了流入坐骨神经轴突的蛋白质总量。3. 这种蛋白质的轴浆运输以两种速率进行：高速率（300毫米/天）和低速率（2毫米/天）。虽然两组蛋白质都受到影响，但秋水仙碱对蛋白质的慢速运输阻断作用更强。4. 结果表明，轴浆运输依赖于轴突中的神经微管系统。
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