黑腹果蝇分离畸变染色体间雄性育性的互补分析。
Complementation analysis of male fertility among the segregation distorter chromosomes of Drosophila melanogaster.
作者信息
Hartl D L
出版信息
Genetics. 1973 Apr;73(4):613-29. doi: 10.1093/genetics/73.4.613.
The fecundities of 55 genotypes of the form SD(i)/SD(j) generated by 11 different SD chromosomes have been examined. Five of the genotypes are lethal The fecundities of the rest fall into a pattern of fertility and sterility that is highly suggestive of intracistronic complementation. The complementation leading to male fertility is only partial complementation: the fecundity of most fertile genotypes is less than half that of controls. The three components of the SD system, the Sd locus, the Ac locus, and the modifiers in 2R, were examined separately, and it appears that the complementation is a phenomenon associated with the Sd locus. A hypothesis of the molecular events involved in segregation distortion is formulated in the light of these observations. The model is based on the assumption that the Sd locus produces a multimeric molecule that regulates the activity of the Ac(=Rsp) locus during spermatogenesis.
我们检测了由11种不同的SD染色体产生的55种SD(i)/SD(j)基因型的生育力。其中5种基因型是致死的，其余基因型的生育力呈现出可育和不育的模式，这强烈暗示了顺反子内互补。导致雄性可育的互补只是部分互补：大多数可育基因型的生育力不到对照的一半。我们分别检测了SD系统的三个组成部分，即Sd位点、Ac位点和2R中的修饰因子，结果表明互补是一种与Sd位点相关的现象。根据这些观察结果，我们提出了一个关于分离畸变所涉及分子事件的假说。该模型基于这样的假设：Sd位点产生一种多聚体分子，在精子发生过程中调节Ac(=Rsp)位点的活性。
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