细菌孢子萌发过程中的脱氧核糖核酸合成与脱氧核苷酸代谢
Deoxyribonucleic acid synthesis and deoxynucleotide metabolism during bacterial spore germination.
作者信息
Setlow P
出版信息
J Bacteriol. 1973 Jun;114(3):1099-107. doi: 10.1128/jb.114.3.1099-1107.1973.
Abstract
Deoxyribonucleic acid (DNA) synthesis during germination of Bacillus megaterium spores takes place in two stages. In stage I (0-55 min) DNA synthesis is slow and there is no detectable net synthesis, whereas in stage II (from 55 min on) the rate of synthesis is much faster and net DNA synthesis occurs. Deoxyribonucleotide pool sizes match the rates of DNA synthesis in stages I and II. The level of deoxyribonucleotide triphosphates is not correlated with the level of deoxyribonucleotide kinases, but rather with that of ribonucleotide reductase activity.
摘要
巨大芽孢杆菌孢子萌发过程中的脱氧核糖核酸（DNA）合成分为两个阶段。在第一阶段（0 - 55分钟），DNA合成缓慢，没有可检测到的净合成，而在第二阶段（从55分钟开始），合成速率快得多，并且发生了净DNA合成。脱氧核苷酸库的大小与第一阶段和第二阶段的DNA合成速率相匹配。三磷酸脱氧核苷酸的水平与脱氧核苷酸激酶的水平无关，而是与核糖核苷酸还原酶活性的水平相关。
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