用冷冻断裂技术重新审视Jimpy小鼠髓磷脂。

Jimpy mouse myelin revisited with freeze-fracture.

作者信息

Privat A, Drian M J, Escaig J

出版信息

Acta Neuropathol. 1979 Feb 15;45(2):129-31. doi: 10.1007/BF00691890.

PMID:419935

Abstract

Corpus callosum, cerebellum, and spinal cord from Jimpy mice, and control littermates, 15 and 21 days old, were prepared for freeze-fracture in a "cryofract" apparatus. The few myelinated axons in the Jimpy exhibited a striking paucity of particles in myelin P faces, though tight junctions were present. In addition, small maculae of particles were found on these P faces. Peripheral myelin appeared normal, both for the quantity and disposition of particles on their P faces.

摘要

取自15日龄和21日龄的Jimpy小鼠及其同窝对照小鼠的胼胝体、小脑和脊髓，在“低温断裂”装置中进行冷冻断裂处理。Jimpy小鼠中少数有髓鞘的轴突在髓鞘P面的颗粒明显稀少，尽管存在紧密连接。此外，在这些P面上发现了小的颗粒斑。外周髓鞘在P面上颗粒的数量和分布方面看起来正常。