Philipson A
Acta Obstet Gynecol Scand. 1979;58(1):69-71. doi: 10.3109/00016347909154918.
Earlier studies have shown that ampicillin produces 50% lower-and therefore very likely less adequate-plasma levels in pregnant than in nonpregnant women. The present investigation compares levels of ampicillin in plasma and urine produced by a single oral dose administered to 10 healthy women taking oral contraceptives on the 21st and on the 28th day of the menstruation cycle. Plasma levels of ampicillin were lower on the 21st day than on the 28th, i.e. a difference in the same direction as between pregnant and nonpregnant women although the difference was not significant. Contrary to what was found for pregnant women the dose of ampicillin to women taking oral contraceptives does not have to be doubled in order to compensate for lower plasma levels.
早期研究表明，氨苄西林在孕妇体内产生的血浆水平比非孕妇低50%，因此很可能不太充足。本研究比较了在月经周期的第21天和第28天给10名服用口服避孕药的健康女性单次口服一剂氨苄西林后，其血浆和尿液中氨苄西林的水平。第21天的氨苄西林血浆水平低于第28天，即与孕妇和非孕妇之间的差异方向相同，尽管差异不显著。与孕妇的情况相反，服用口服避孕药的女性不必将氨苄西林剂量加倍以补偿较低的血浆水平。
