Synaptosomal accumulation of intracerebrally injected amino acids.

The distribution of the labels of [35S]taurine, [3H]lysine, [14C]glutamate and [14C]norleucine in mouse brain subcellular fractions was followed after intracerebral injection in vivo. [35S]taurine, [3H]lysine and [14C]glutamate and its metabolites accumulated in the nerve terminals, lysine and glutamate also occurring in the synaptic vesicles, while remained mainly in soluble synaptoplasm [14C] nor leucine penetrated the brain cell membranes slowly, but was still bound to the synaptic vesicles to a greater extent than taurine.