Rassin D K, Sturman J A, Hayes K C, Gaull G E
Neurochem Res. 1978 Aug;3(4):401-10. doi: 10.1007/BF00966322.
Taurine concentration decreases rapidly in the tissues and physiological fluids of kittens fed a diet of partially purified casein which lacks taurine. We have studied the subcellular distribution in cerebrum of taurine and [35S]taurine administered intravenously to these animals. The taurine concentration of all the fractions isolated from the cerebrum of taurine-deficient kittens was approximately sevenfold less than that observed in the fractions of cerebrum isolated from control kittens. The [35S]taurine was approximately twofold greater in all the brain fractions isolated from the taurine-deficient kittens compared with those isolated from the control kittens. The percent distributions of taurine and [35S]taurine in the fractions isolated from the cerebrum of control and deficient kittens were identical. Thus, in the face of a severe diet-induced deficiency of taurine in kitten brain, there appears to be no conservation of taurine by any particular subcellular pool of taurine. These studies provide no evidence for differences in compartmentation of taurine in cerebrum of taurine-deficient kittens compared with control kittens.
用缺乏牛磺酸的部分纯化酪蛋白饮食喂养的小猫，其组织和生理液中的牛磺酸浓度会迅速下降。我们研究了给这些动物静脉注射牛磺酸和[35S]牛磺酸后，它们大脑中的亚细胞分布情况。从缺乏牛磺酸的小猫大脑中分离出的所有组分中的牛磺酸浓度，比从对照小猫大脑中分离出的组分中的牛磺酸浓度低约七倍。与从对照小猫中分离出的大脑组分相比，从缺乏牛磺酸的小猫中分离出的所有大脑组分中的[35S]牛磺酸含量大约高两倍。从对照小猫和缺乏牛磺酸的小猫大脑中分离出的组分中，牛磺酸和[35S]牛磺酸的百分比分布是相同的。因此，在小猫大脑因饮食导致严重缺乏牛磺酸的情况下，似乎没有任何特定的牛磺酸亚细胞池对牛磺酸进行保留。这些研究没有提供证据表明，与对照小猫相比，缺乏牛磺酸的小猫大脑中牛磺酸的区室化存在差异。
