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亮氨酸饥饿对枯草芽孢杆菌不同脱氧核糖核酸调控菌株中核糖核酸合成控制的影响。

Effects of leucine starvation on control of ribonucleic acid synthesis in strains of Bacillus subtilis differing in deoxyribonucleic acid regulation.

作者信息

Thomas J E, Copeland J C

出版信息

J Bacteriol. 1973 Nov;116(2):938-43. doi: 10.1128/jb.116.2.938-943.1973.

DOI:10.1128/jb.116.2.938-943.1973
PMID:4200861
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC285466/
Abstract

When starved for leucine, strains of Bacillus subtilis do not complete chromosome replication to the terminus. The amount of deoxyribonucleic acid (DNA) made poststarvation is characteristic of the strain. In this study, four strains differing in their DNA response were examined for ribonucleic acid (RNA) regulation during leucine starvation. Each of the strains was judged to be stringent for RNA control based on the amount of RNA made poststarvation. Sucrose gradient profiles on RNA made with and without leucine starvation support this conclusion. Accumulation of guanosine tetraphosphate during leucine starvation showed no correlation with the amount of DNA synthesized. We concluded that modulation control of DNA synthesis during leucine starvation is independent of RNA control.

摘要

当枯草芽孢杆菌菌株缺乏亮氨酸时，它们无法将染色体复制完成至终点。饥饿后合成的脱氧核糖核酸（DNA）量具有菌株特异性。在本研究中，检测了四种DNA反应不同的菌株在亮氨酸饥饿期间的核糖核酸（RNA）调控情况。根据饥饿后产生的RNA量，判断每种菌株对RNA控制均为严格型。有无亮氨酸饥饿条件下RNA的蔗糖梯度图谱支持这一结论。亮氨酸饥饿期间四磷酸鸟苷的积累与合成的DNA量无关。我们得出结论，亮氨酸饥饿期间DNA合成的调控控制独立于RNA控制。

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本文引用的文献

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