枯草芽孢杆菌中染色体复制的调控：W23菌株中氨基酸饥饿的影响。
Regulation of chromosome replication in Bacillus subtilis: effects of amino acid starvation in strain W23.
作者信息
Copeland J C
出版信息
J Bacteriol. 1971 Feb;105(2):595-603. doi: 10.1128/jb.105.2.595-603.1971.
Abstract
Amino acid starvation allows limited synthesis of deoxyribonucleic acid (DNA) in Bacillus subtilis strain W23. DNA synthesis increased by about 30% after leucine starvation and by about 60% after histidine starvation. Genetic analysis on the DNA synthesized after amino acid starvation showed that all genetic markers examined have replicated, regardless of which amino acid was starved for. Initially, all markers replicated equally, but upon further replication, the thr cysB and the argA to lys regions replicated ahead of their neighboring, proximal regions. This could indicate that preferred stopping sites exist in these regions or additional sites from which replication can originate reside there. The results suggest that chromosome replication continues from those sites where it had stopped during amino acid starvation.
摘要
氨基酸饥饿时，枯草芽孢杆菌W23菌株中脱氧核糖核酸（DNA）的合成受限。亮氨酸饥饿后，DNA合成增加约30%，组氨酸饥饿后增加约60%。对氨基酸饥饿后合成的DNA进行遗传分析表明，所检测的所有遗传标记均已复制，无论饥饿的是哪种氨基酸。最初，所有标记均等量复制，但在进一步复制时，苏氨酸 - 胱氨酸B区域以及精氨酸A到赖氨酸区域比其相邻的近端区域复制得更快。这可能表明这些区域存在优先终止位点，或者存在额外的复制起始位点。结果表明，染色体复制从氨基酸饥饿期间停止的位点继续进行。
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