阿朴啡类化合物。8. （±）-阿扑吗啡、（±）-阿朴可待因、（±）-N-正丙基去甲阿扑吗啡及（±）-N-正丙基去甲阿朴可待因的全合成及药理评价 - Suppr

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Aporphines. 8. Total synthesis and pharmacological evaluation of (plus or minus)-apomorphine, (plus or minus)-apocodeine, (plus or minus)-N-n-propylnorapomorphine, and (plus or minus)-N-n-propylnorapocodeine.

作者信息

Neumeyer J L, Neustadt B R, Oh K H, Weinhardt K K, Boyce C B, Rosenberg F J, Teiger D G

出版信息

J Med Chem. 1973 Nov;16(11):1223-8. doi: 10.1021/jm00269a601.

DOI:10.1021/jm00269a601

PMID:4201182

Abstract

摘要

相似文献

Aporphines. 8. Total synthesis and pharmacological evaluation of (plus or minus)-apomorphine, (plus or minus)-apocodeine, (plus or minus)-N-n-propylnorapomorphine, and (plus or minus)-N-n-propylnorapocodeine.阿朴啡类化合物。8. （±）-阿扑吗啡、（±）-阿朴可待因、（±）-N-正丙基去甲阿扑吗啡及（±）-N-正丙基去甲阿朴可待因的全合成及药理评价

J Med Chem. 1973 Nov;16(11):1223-8. doi: 10.1021/jm00269a601.

Aporphines. 11. Synthesis and dopaminergic acitivity of monohydroxyaporphines. Total synthesis of (plus, minus)-11-hydroxyaporphine, (plus and minus)-11-hydroxynoraporphine, and (plus, minus)-11-hydroxy-N-n-propylnoraporphine.

J Med Chem. 1974 Oct;17(10):1090-5. doi: 10.1021/jm00256a014.

Centrally acting emetics. 5. Preparation and pharmacology of 10-hydroxy-11 methoxyaporphine (isoapocodeine). In vitro enzymatic methylation of apomorphine.中枢性催吐药。5. 10-羟基-11-甲氧基阿朴啡（异阿朴可待因）的制备与药理学。阿朴吗啡的体外酶促甲基化。

J Med Chem. 1972 Mar;15(3):273-6. doi: 10.1021/jm00273a016.

Centrally acting emetics. 7. Hofmann and Emde degradation products of apomorphine.

J Med Chem. 1973 Mar;16(3):219-24. doi: 10.1021/jm00261a011.

Synthesis and biological activity of (6aS)-10,11-dihydroxyaporphine, the optical antipode of apomorphine.

J Med Chem. 1973 Feb;16(2):171-2. doi: 10.1021/jm00260a022.

Centrally acting emetics. 9. Hofmann and Emde degradation products of nuciferine.中枢性催吐剂。9. 荷叶碱的霍夫曼和埃德降解产物。

J Med Chem. 1975 Jan;18(1):110-2. doi: 10.1021/jm00235a026.

Emetic activity of N-substituted norapomorphines.N-取代去甲阿扑吗啡的催吐活性。

J Med Chem. 1975 Oct;18(10):1000-3. doi: 10.1021/jm00244a010.

Synthesis and biological activity of some aporphine derivatives related to apomorphine.一些与阿扑吗啡相关的阿朴菲衍生物的合成及生物活性

J Med Chem. 1974 Oct;17(10):1086-90. doi: 10.1021/jm00256a013.

Derivatives of apomorphine and of other N-substituted norapomorphines.阿扑吗啡及其他N-取代去甲阿扑吗啡的衍生物。

J Pharm Sci. 1976 Nov;65(11):1682-5. doi: 10.1002/jps.2600651129.

Aporphines. 16. Action of aporphine alkaloids on locomotor activity in rats with 6-hydroxydopamine lesions of the nucleus accumbens.阿朴啡类。16. 阿朴啡生物碱对伏隔核6-羟基多巴胺损伤大鼠运动活性的作用。

Eur J Pharmacol. 1976 Jan;35(1):85-92. doi: 10.1016/0014-2999(76)90303-4.

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