Synthesis and biological activity of (6aS)-10,11-dihydroxyaporphine, the optical antipode of apomorphine.
作者信息
Saari W S, King S W
出版信息
J Med Chem. 1973 Feb;16(2):171-2. doi: 10.1021/jm00260a022.
PMID:4683115
Abstract
摘要
相似文献
1
Synthesis and biological activity of (6aS)-10,11-dihydroxyaporphine, the optical antipode of apomorphine.
J Med Chem. 1973 Feb;16(2):171-2. doi: 10.1021/jm00260a022.
2
Aporphines. 8. Total synthesis and pharmacological evaluation of (plus or minus)-apomorphine, (plus or minus)-apocodeine, (plus or minus)-N-n-propylnorapomorphine, and (plus or minus)-N-n-propylnorapocodeine.阿朴啡类化合物。8. （±）-阿扑吗啡、（±）-阿朴可待因、（±）-N-正丙基去甲阿扑吗啡及（±）-N-正丙基去甲阿朴可待因的全合成及药理评价
J Med Chem. 1973 Nov;16(11):1223-8. doi: 10.1021/jm00269a601.
3
Centrally acting emetics. 8. Conformational aspects of certain dihydrophenanthrene congeners of apomorphine.中枢性催吐药。8. 阿扑吗啡某些二氢菲同系物的构象方面
J Med Chem. 1975 Jan;18(1):108-10. doi: 10.1021/jm00235a025.
4
Centrally acting emetics. 5. Preparation and pharmacology of 10-hydroxy-11 methoxyaporphine (isoapocodeine). In vitro enzymatic methylation of apomorphine.中枢性催吐药。5. 10-羟基-11-甲氧基阿朴啡（异阿朴可待因）的制备与药理学。阿朴吗啡的体外酶促甲基化。
J Med Chem. 1972 Mar;15(3):273-6. doi: 10.1021/jm00273a016.
5
Emetic activity of N-substituted norapomorphines.N-取代去甲阿扑吗啡的催吐活性。
J Med Chem. 1975 Oct;18(10):1000-3. doi: 10.1021/jm00244a010.
6
Synthesis and biological activity of some aporphine derivatives related to apomorphine.一些与阿扑吗啡相关的阿朴菲衍生物的合成及生物活性
J Med Chem. 1974 Oct;17(10):1086-90. doi: 10.1021/jm00256a013.
7
Derivatives of apomorphine and of other N-substituted norapomorphines.阿扑吗啡及其他N-取代去甲阿扑吗啡的衍生物。
J Pharm Sci. 1976 Nov;65(11):1682-5. doi: 10.1002/jps.2600651129.
8
Ergometrine and apomorphine as selective antagonists of dopamine in the canine renal vasculature.麦角新碱和阿扑吗啡作为犬肾血管中多巴胺的选择性拮抗剂。
Br J Pharmacol. 1974 Dec;52(4):591-5. doi: 10.1111/j.1476-5381.1974.tb09728.x.
9
Centrally acting emetics. II. Norapomorphine and derivatives.中枢性催吐药。II. 去甲阿扑吗啡及其衍生物。
J Med Chem. 1968 Sep;11(5):977-81. doi: 10.1021/jm00311a014.
10
Centrally acting emetics. 9. Hofmann and Emde degradation products of nuciferine.中枢性催吐剂。9. 荷叶碱的霍夫曼和埃德降解产物。
J Med Chem. 1975 Jan;18(1):110-2. doi: 10.1021/jm00235a026.
引用本文的文献
1
Pharmacological Insights into the Use of Apomorphine in Parkinson's Disease: Clinical Relevance.阿扑吗啡在帕金森病中的应用的药理学研究进展：临床相关性。
Clin Drug Investig. 2018 Apr;38(4):287-312. doi: 10.1007/s40261-018-0619-3.
2
S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis.S[+]阿扑吗啡是一种可穿透中枢神经系统的Nrf2-ARE途径激活剂，在肌萎缩侧索硬化症的小鼠和患者成纤维细胞模型中具有活性。
Free Radic Biol Med. 2013 Aug;61:438-52. doi: 10.1016/j.freeradbiomed.2013.04.018. Epub 2013 Apr 19.
3
Structure-activity relationships for apomorphine congeners. Conformational energies vs. biological activities.阿扑吗啡类似物的构效关系。构象能与生物活性的关系。
J Comput Aided Mol Des. 1987 Jul;1(2):143-52. doi: 10.1007/BF01676958.
4
Behavioral effects of apomorphine isomers in the rat: selective locomotor-inhibitory effects of S(+)N-n-propylnorapomorphine.阿扑吗啡异构体对大鼠的行为影响：S(+)N-正丙基去甲阿扑吗啡的选择性运动抑制作用
Psychopharmacology (Berl). 1986;88(2):158-64. doi: 10.1007/BF00652233.
5
Conformations and biological properties of apomorphine and its phenanthro(10,1-b,c)azepine homologue.
Experientia. 1975 Nov 15;31(11):1327-8. doi: 10.1007/BF01945809.
Zotero 插件