Bikle D D, Hagler L, Lollini L O, Hull S F, Herman R H
Am J Clin Nutr. 1979 Mar;32(3):515-6. doi: 10.1093/ajcn/32.3.515.
To determine if vitamin D deficiency would retard the ability of muscle to hypertrophy in response to mechanical stress, we severed the gastrocnemius tendon on one leg of rats in each of three groups, the treatment of which differed only in the amount of vitamin D in the diet. After 1 week the increased size of the soleus and plantaris in the leg in which the gastrocnemius was severed relative to that of the sham operated leg, was determined for each rat. Despite differences in body weight and serum calcium among the groups, we found no difference in the percent of muscle hypertrophy. We conclude that muscle hypertrophy can occur in response to local mechanical forces despite a deficient hormonal environment that otherwise retards growth.
为了确定维生素D缺乏是否会阻碍肌肉在机械应力作用下的肥大能力，我们将三组大鼠每组中一只腿的腓肠肌腱切断，三组的处理仅在饮食中维生素D的含量上有所不同。1周后，测定每只大鼠中腓肠肌被切断的腿比假手术腿中比目鱼肌和跖肌增大的尺寸。尽管各组之间体重和血清钙存在差异，但我们发现肌肉肥大百分比并无差异。我们得出结论，尽管存在激素环境不足会阻碍生长的情况，但肌肉仍可因局部机械力而发生肥大。
