Norton J A, Lowry S F, Brennan M F
J Appl Physiol Respir Environ Exerc Physiol. 1979 Apr;46(4):654-7. doi: 10.1152/jappl.1979.46.4.654.
Synergistic muscles (soleus and plantaris) from a gastrocnemius-tenotomized hindlimb were compared to the same muscles in a sham-operated hindlimb in both tumor-bearing and non tumor-bearing rats. In nontumor-bearing animals muscle from the tenotomized hindlimb had a significant increase in wet weight (26%), percent-water (5%), and total nitrogen/muscle (10%) consistent with muscular hypertrophy. In tumor-bearing animals, muscle from the tenotomized hindlimb had a significant increase in wet weight and percent water, but there was no significant difference in total nitrogen/muscle. As the tumor burden increased, the final muscle weight, in both the tenotomized and sham-operated hindlimb, was found to decrease proportionately. Only in animals with large (23% body wt) tumor burdens did hypertrophied muscle weigh significantly less than sham-operated muscle from nontumor-bearing animals. This indicated that, in rats with large tumor burdens, work-induced hypertrophy was unable to preserve muscle mass despite the fact that hypertrophied muscle was 24% heavier than contralateral sham-operated muscle.
将来自跟腱切断后肢的协同肌（比目鱼肌和跖肌）与假手术处理后肢的相同肌肉进行比较，比较对象包括荷瘤大鼠和非荷瘤大鼠。在非荷瘤动物中，跟腱切断后肢的肌肉湿重显著增加（26%）、含水量增加（5%）、总氮/肌肉增加（10%），这与肌肉肥大一致。在荷瘤动物中，跟腱切断后肢的肌肉湿重和含水量显著增加，但总氮/肌肉没有显著差异。随着肿瘤负荷增加，发现跟腱切断和假手术处理的后肢的最终肌肉重量均成比例下降。只有在肿瘤负荷大（占体重23%）的动物中，肥大肌肉的重量才显著低于非荷瘤动物假手术处理的肌肉。这表明，在肿瘤负荷大的大鼠中，尽管肥大肌肉比同侧假手术处理的肌肉重24%，但工作诱导的肥大仍无法维持肌肉质量。
