秋水仙碱导致膜成分流动性受损的直接证据。
Direct evidence for a colchicine-induced impairment in the mobility of membrane components.
作者信息
Wunderlich F, Müller R, Speth V
出版信息
Science. 1973 Dec 14;182(4117):1136-8. doi: 10.1126/science.182.4117.1136.
PMID:4201508
Abstract
Freeze-etch electron microscopy was used to show that colchicine interacts with membranes of the ciliate protozoan Tetrahymena pyriformis. Colchicine impairs the temperature-induced translational and vertical mobility of the membrane-intercalating particles of the freeze-fractured alveolar membranes lying just below the plasma membranes.
摘要
冷冻蚀刻电子显微镜被用于显示秋水仙碱与梨形四膜虫这种纤毛原生动物的膜相互作用。秋水仙碱会损害位于质膜下方的冷冻断裂肺泡膜的膜嵌入颗粒的温度诱导平移和垂直移动性。
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