Goldman S L
Am J Dis Child. 1979 Feb;133(2):181-3. doi: 10.1001/archpedi.1979.02130020073015.
Hyperglycemic hyperosmolar coma is a life-threatening emergency with a mortality much higher than that of other forms of hyperosmolarity such as hypernatremia or diabetic ketoacidosis. Despite the differences in the three conditions, present evidence suggests that correction of hyperosmolarity should proceed slowly to avoid the seizures that may occur in all three conditions. This report describes a 9-month-old diabetic child who initially had hyperglycemic hyperosmolar coma and who is one of the youngest survivors of this syndrome in the American literature. This case report points out the limited understanding of the pathophysiology of this syndrome and the consequent problems of therapy.
高血糖高渗性昏迷是一种危及生命的急症，其死亡率远高于其他形式的高渗状态，如高钠血症或糖尿病酮症酸中毒。尽管这三种情况有所不同，但现有证据表明，高渗状态的纠正应缓慢进行，以避免在这三种情况下都可能出现的癫痫发作。本报告描述了一名9个月大的糖尿病患儿，该患儿最初患有高血糖高渗性昏迷，是美国文献中该综合征最年轻的幸存者之一。本病例报告指出了对该综合征病理生理学的了解有限以及由此产生的治疗问题。
