在用枸橼酸氯米芬预处理的大鼠中，慢性给予吲哚美辛后睾丸δ5-3β-羟基类固醇脱氢酶和17β-羟基类固醇脱氢酶的组织化学研究。
Histochemical studies of testicular delta5-3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase after chronic indomethacin administration in rats pretreated with clomiphene-citrate.
作者信息
Sanyal S, Patra P B, Biswas N M
出版信息
Andrologia. 1979 Jan;11(1):51-6. doi: 10.1111/j.1439-0272.1979.tb02160.x.
Abstract
Histochemical studies of testicular delta5-3beta-Hydroxysteroid Dehydrogenase and 17beta-Hydroxysteroid Dehydrogenase in sexually immature rats treated chronically with simultaneous Indomethacin and Clomiphene revealed greater inhibition in the enzyme activities when compared to Clomiphene treated animals alone. This suggests prostaglandin-inhibitors may be directly inhibitory to NAD-requiring enzymes involved in testicular steroid biosynthesis.
摘要
对长期同时用吲哚美辛和克罗米芬治疗的性未成熟大鼠睾丸δ5-3β-羟基类固醇脱氢酶和17β-羟基类固醇脱氢酶进行的组织化学研究显示，与单独用克罗米芬治疗的动物相比，酶活性受到更大抑制。这表明前列腺素抑制剂可能直接抑制参与睾丸类固醇生物合成的需NAD的酶。
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