Leff A, Herskowitz D, Gibert J, Brewin A
Am Rev Respir Dis. 1979 Jan;119(1):161-70. doi: 10.1164/arrd.1979.119.1.161.
A survey of tuberculosis chemoprophylaxis policies was conducted from September 1977 through January 1978 of all metropolitan programs in the United States that reported more than 100 cases of tuberculosis during 1976. Twenty-eight programs were surveyed, and all responded. Uniform practice was found with regard to the dosage of isoniazid administered, duration of treatment, and most other indications for preventive therapy recommended by the American Thoracic Society and the U.S. Public Health Service Center for Disease Control. One third of the programs surveyed administered chemoprophylaxis to pregnant women, and one third regularly dispensed more than a one-month supply of isoniazid to patients. Three programs (11%) routinely monitored hepatic function by serum laboratory tests during chemoprophylaxis. Four programs (14%) regularly or occasionally used bacillus Calmette-Guérin vaccine for prevention of tuberculosis. Although large metropolitan programs generally followed the guidelines of the American Thoracic Society and the Center for Disease Control for tuberculosis chemoprophylaxis, some major variances in practice were reported.
1977年9月至1978年1月，对美国所有大城市项目进行了一项关于结核病化学预防政策的调查，这些项目在1976年报告的结核病病例超过100例。共调查了28个项目，所有项目均作出了回应。结果发现，在所使用的异烟肼剂量、治疗持续时间以及美国胸科学会和美国公共卫生服务疾病控制中心推荐的预防性治疗的大多数其他指征方面，做法是一致的。接受调查的项目中有三分之一对孕妇进行化学预防，三分之一的项目经常给患者发放超过一个月用量的异烟肼。三个项目（11%）在化学预防期间通过血清实验室检测常规监测肝功能。四个项目（14%）经常或偶尔使用卡介苗预防结核病。虽然大城市的大型项目一般遵循美国胸科学会和疾病控制中心关于结核病化学预防的指导方针，但报告了一些实际做法上的重大差异。
