Asakuma S, Lowry L D, Snow J B
Arch Otolaryngol. 1979 Mar;105(3):145-8. doi: 10.1001/archotol.1979.00790150035009.
The magnitudes of the endocochlear dc potential (EP) during adequate ventilation and during five minutes of anoxia were recorded in control guinea pigs and guinea pigs administered various dosages of kanamycin sulfate. The magnitudes of the EP after five minutes of anoxia were -44.6 +/- 5.9 mV in the controls and +26.6 +/- 9.9 mV in the guinea pigs that received kanamycin for seven or ten days. This change occurred after five or six days of administration of kanamycin. However, there was no significant change in the magnitude ot the EP with adequate ventilation with kanamycin intoxication. There is a significant correlation between the magnitude of the negative EP and the maximum output of the cochlear microphonics (r = -.770, P less than .001). These results suggest that the EP may not be the mathematical summation of the positive electrogenic potential and the negative diffusion potential. The mechanism for generating the negative EP during anoxia may have some relationship to hair cell integrity.
记录了正常通气期间及缺氧5分钟时，对照豚鼠和给予不同剂量硫酸卡那霉素的豚鼠的内耳蜗直流电位（EP）大小。缺氧5分钟后，对照组的EP大小为-44.6±5.9 mV，接受卡那霉素7天或10天的豚鼠的EP大小为+26.6±9.9 mV。这种变化发生在卡那霉素给药5或6天后。然而，在卡那霉素中毒且通气充分的情况下，EP大小没有显著变化。负EP大小与耳蜗微音器的最大输出之间存在显著相关性（r = -0.770，P < 0.001）。这些结果表明，EP可能不是正生电电位和负扩散电位的数学总和。缺氧期间产生负EP的机制可能与毛细胞完整性有某种关系。
