Phillips P E, Kassan S S, Kagen L J
Arthritis Rheum. 1979 Mar;22(3):209-14. doi: 10.1002/art.1780220301.
Antibodies to Toxoplasma gondii were measured in sera from 69 patients with polymyositis, dermatomyositis, and myositis associated with other connective tissue diseases and compared to 69 age-, race-, and sex-matched controls with unrelated diseases. Complement fixation toxoplasma antibodies were significantly more frequent in polymyositis and correlated with high IgM levels. Other distinguishing clinical or laboratory features of these patients were not found. The high toxoplasma antibodies were not associated with generally hyperactive humoral immunity. The serologic data suggested that inflammatory muscle disease was associated with recent active toxoplasma infection in certain patients. The pathogenetic role of the microorganism remains uncertain.
检测了69例患有多发性肌炎、皮肌炎以及与其他结缔组织病相关的肌炎患者血清中的弓形虫抗体，并与69例年龄、种族和性别匹配的患无关疾病的对照者进行比较。补体结合弓形虫抗体在多发性肌炎患者中明显更常见，且与高IgM水平相关。未发现这些患者有其他明显的临床或实验室特征。高弓形虫抗体与普遍活跃的体液免疫无关。血清学数据表明，在某些患者中，炎性肌病与近期活跃的弓形虫感染有关。该微生物的致病作用仍不确定。
