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[系统性红斑狼疮、多发性肌炎与弓形虫抗体]

[Systemic lupus erythematosus, polymyositis and toxoplasma antibodies].

作者信息

Hamza M, Maalej A, Ayed K, Moalla M, Ben Rachid M, Ben Ayed H

出版信息

Sem Hop. 1983 Jan 6;59(1):43-6.

PMID:6297086
Abstract

High toxoplasma antibody titers have been reported in polymyositis and other connectivitis with myositis. The authors describe a case of systemic lupus erythematosus with polymyositis and high titers of IgG toxoplasma antibodies. Studies of muscle biopsy specimens by immunofluorescence and inoculation of mice with muscle extracts failed to demonstrate the presence of Toxoplasma gondii. The nature of the toxoplasmic agression is discussed. It may be that reactivation of a previous infection due to the rupture of cysts was promoted by the immunologic disorders and complement deficiency related to systemic lupus erythematosus.

摘要

在多发性肌炎及其他伴有肌炎的结缔组织炎中,曾有高弓形虫抗体滴度的报道。作者描述了一例患有多发性肌炎且IgG弓形虫抗体滴度高的系统性红斑狼疮病例。通过免疫荧光对肌肉活检标本进行研究,以及用肌肉提取物接种小鼠,均未能证明存在刚地弓形虫。本文讨论了弓形虫侵袭的性质。可能是由于与系统性红斑狼疮相关的免疫紊乱和补体缺乏,促使先前感染的囊肿破裂后重新激活。

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