一种与人类肝脏N-乙酰-β-D-氨基葡萄糖苷酶发生交叉反应的低分子量蛋白质。
A low-molecular-weight protein cross-reacting with human liver N-acetyl-beta-D-glucosaminidase.
作者信息
Carroll M, Robinson D
出版信息
Biochem J. 1974 Feb;137(2):217-21. doi: 10.1042/bj1370217.
Abstract
Antisera were raised to preparations of hexosaminidase isoenzymes A and B purified from human liver. Protein that cross-reacted with the liver hexosaminidase was detected by an antibody-consumption method. A cross-reacting protein with a low molecular weight (20000) was partially characterized and purified from control human liver. This protein is also present in the liver of patients with Tay-Sachs disease or with Sandhoff's disease. Hexosaminidases A and B gave an immunological reaction of partial identity with the low-molecular-weight protein. The possible identity of the low-molecular-weight cross-reacting protein as a subunit of hexosaminidase is discussed.
摘要
制备了针对从人肝脏中纯化的己糖胺酶同工酶A和B的抗血清。通过抗体消耗法检测与肝脏己糖胺酶发生交叉反应的蛋白质。从对照人肝脏中部分鉴定并纯化了一种低分子量（20000）的交叉反应蛋白。这种蛋白也存在于患有泰-萨克斯病或桑德霍夫病患者的肝脏中。己糖胺酶A和B与低分子量蛋白发生部分同源的免疫反应。讨论了低分子量交叉反应蛋白作为己糖胺酶亚基的可能同源性。
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Nature. 1962 Jul 21;195:281-3. doi: 10.1038/195281a0.
2
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Ann N Y Acad Sci. 1963 May 8;103:735-43. doi: 10.1111/j.1749-6632.1963.tb53730.x.
3
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Nature. 1961 Dec 23;192:1187. doi: 10.1038/1921187a0.
4
Variation of beta-N-acetylhexosaminidase-pattern in Tay-Sachs disease.泰-萨克斯病中β-N-乙酰己糖胺酶模式的变化。
FEBS Lett. 1969 Aug;4(4):351-354. doi: 10.1016/0014-5793(69)80274-7.
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Science. 1969 Aug 15;165(3894):698-700. doi: 10.1126/science.165.3894.698.
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