Møller S E, Amdisen A
Biol Psychiatry. 1979 Feb;14(1):131-9.
The free tryptophan and plasma neutral amino acids including kynurenine have been determined before treatment, after a single load, and during prolonged treatment with L-tryptophan on a bipolar manic-depressive patient who has shown resistance to current treatments. The data of the patient were compared with the data of healthy control subjects in order to evaluate the availability of tryptophan to the brain. A relative deficiency of tryptophan in the plasma, as measured by the ratio of tryptophan to those amino acids which compete with tryptophan during transport processes, was found in the patient. Further, the patient showed an increased area under curve of plasma tryptophan after a load, and an increase in the competing amino acids during the load compared to a decrease in the control subjects. During the treatment with L-tryptophan the competing amino acids increased in the plasma. The results suggest that the patient suffered from a dysfunction of the processes which mediate active transport of tryptophan and other large neutral amino acids into tissues including the brain.
对一名对当前治疗有抵抗性的双相躁郁症患者，在治疗前、单次负荷后以及长期使用L-色氨酸治疗期间，测定了其游离色氨酸以及包括犬尿氨酸在内的血浆中性氨基酸。将该患者的数据与健康对照受试者的数据进行比较，以评估色氨酸向大脑的可用性。通过色氨酸与在转运过程中与其竞争的氨基酸的比例来衡量，发现该患者血浆中色氨酸相对缺乏。此外，该患者在负荷后血浆色氨酸曲线下面积增加，与对照受试者减少相比，负荷期间竞争氨基酸增加。在使用L-色氨酸治疗期间，血浆中竞争氨基酸增加。结果表明，该患者存在介导色氨酸和其他大型中性氨基酸主动转运至包括大脑在内的组织的过程功能障碍。
