Møller S E, Kirk L
Acta Vitaminol Enzymol. 1978;32(5-6):159-62.
The effect of allopurinol on the kynurenine formation in three manic depressive patients, two in remission and on in depression, has been studied during long-term treatment with L-tryptophan. The patients were loaded with 100 mg L-tryptophan per Kg body weight prior to and after one week on allopurinol, 300 to 500 mg per day. The area under curve (AUC) of plasma total and free tryptophan increased slightly in the patients in remission but not in the depressive. The former showed no change in the AUC of plasma kynurenine whereas an increase was seen in the depressive. The results suggest that allopurinol does not inhibit the human tryptophan pyrrolase definitely during loadings with L-tryptophan.
在对三名躁郁症患者（两名处于缓解期，一名处于抑郁期）进行L-色氨酸长期治疗期间，研究了别嘌呤醇对犬尿氨酸形成的影响。在服用别嘌呤醇（每天300至500毫克）一周之前和之后，给患者每千克体重服用100毫克L-色氨酸。缓解期患者血浆总色氨酸和游离色氨酸的曲线下面积（AUC）略有增加，而抑郁期患者则没有。前者血浆犬尿氨酸的AUC没有变化，而抑郁期患者则有所增加。结果表明，在L-色氨酸负荷期间，别嘌呤醇不能明确抑制人色氨酸吡咯酶。
