黑腹果蝇的性连锁营养缺陷型和假定营养缺陷型突变体。
Sex-linked auxotrophic and putative auxotrophic mutants of Drosophila melanogaster.
作者信息
Falk D R, Nash D
出版信息
Genetics. 1974 Apr;76(4):755-66. doi: 10.1093/genetics/76.4.755.
Abstract
Thirty-two mutants with improved growth response on a yeast-sucrose compared with a defined medium have been characterized with respect to ribonucleoside supplementability. Twenty mutants respond to either pyrimidine ribonucleoside. Four mutants respond to one or both purine ribonucleosides. Eight mutants ("putative" auxotrophs) do not respond to dietary RNA supplementation. Mapping and complementation studies suggest that eleven loci are represented: one, rudimentary, probably accounts for all pyrimidine requirers; there are three purine loci and seven at which the putative auxotrophs are found.
摘要
与限定培养基相比，在酵母蔗糖培养基上生长反应有所改善的32个突变体已就核糖核苷可补充性进行了表征。20个突变体对嘧啶核糖核苷有反应。4个突变体对一种或两种嘌呤核糖核苷有反应。8个突变体（“假定”营养缺陷型）对日粮RNA补充无反应。定位和互补研究表明涉及11个基因座：一个基因座，即残基基因，可能解释了所有嘧啶需求者；有3个嘌呤基因座和7个发现假定营养缺陷型的基因座。
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本文引用的文献
1
Development of Eye Colors in Drosophila: Diffusible Substances and Their Interrelations.果蝇眼色的发育：可扩散物质及其相互关系
Genetics. 1937 Jan;22(1):76-86. doi: 10.1093/genetics/22.1.76.
2
Genetic Control of Biochemical Reactions in Neurospora.粗糙脉孢菌中生化反应的遗传控制。
Proc Natl Acad Sci U S A. 1941 Nov 15;27(11):499-506. doi: 10.1073/pnas.27.11.499.
3
A RIBONUCLEIC ACID-PROTEIN RELATIONSHIP IN DROSOPHILA NUTRITION.果蝇营养中的核糖核酸-蛋白质关系
J Exp Zool. 1963 Dec;154:353-64. doi: 10.1002/jez.1401540309.
4
Complementation among the subgenic mutants in the r-locus of Drosophila melangogaster.黑腹果蝇r基因座亚基因座突变体间的互补作用。
Nature. 1959 Dec 19;184:1927-9. doi: 10.1038/1841927a0.
5
Conversion of 2-amino-4-hydroxypteridine to isoxanthopterin in D. Melanogaster.黑腹果蝇中2-氨基-4-羟基蝶啶向异黄蝶呤的转化。
Science. 1956 Oct 19;124(3225):725-6. doi: 10.1126/science.124.3225.725.
6
Nutritional conditional mutants of Drosophila melanogaster.黑腹果蝇的营养条件突变体。
Genet Res. 1969 Jun;13(3):281-7. doi: 10.1017/s0016672300002974.
7
Localization of 5S RNA genes on Drosophila chromosomes by RNA-DNA hybridization.通过RNA-DNA杂交对果蝇染色体上5S RNA基因进行定位
Science. 1970 Nov 6;170(3958):639-41. doi: 10.1126/science.170.3958.639.
8
A purine and pyrimidine requiring mutant of Drosophila melanogaster.一种需要嘌呤和嘧啶的黑腹果蝇突变体。
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9
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10
Cytological localization of DNA complementary to ribosomal RNA in polytene chromosomes of Diptera.双翅目多线染色体中与核糖体RNA互补的DNA的细胞学定位。
Chromosoma. 1970;29(3):268-90. doi: 10.1007/BF00325943.
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