[苯二氮䓬类镇静剂对大脑γ-氨基丁酸转氨酶活性影响的定量组织化学研究]
[Quantitative histochemical study of the effect of benzodiazepine tranquilizers on cerebral GABA-transaminase activity].
作者信息
Galust'ian G E
出版信息
Biull Eksp Biol Med. 1979 Feb;87(2):164-6.
PMID:420938
Abstract
The effect of diazepam and nitrazepam (0.5, 1, 2.5, and 5 mg/kg) on GABA-transaminase activity in the rat cerebellar cortex and hippocampus was investigated by quantitative histochemistry. Both the drugs suppressed the enzyme activity in the hippocampus; the maximal effect was produced by diazepam. It is suggested that the observed alterations are caused by the enzyme inhibition and also by a decrease of GABA turnover rate.
摘要
通过定量组织化学研究了地西泮和硝西泮（0.5、1、2.5和5毫克/千克）对大鼠小脑皮质和海马中γ-氨基丁酸转氨酶活性的影响。两种药物均抑制海马中的酶活性；地西泮产生的效果最大。研究表明，观察到的变化是由酶抑制以及γ-氨基丁酸周转率降低引起的。
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