Huggins K G, Brostoff J
Clin Allergy. 1979 Jan;9(1):37-42. doi: 10.1111/j.1365-2222.1979.tb01520.x.
We report the finding of anomalous responses in the skin of atopic individuals when prick tested with serial dilutions of cocksfoot grass pollen extracts. Each pollen extract was standardized using RAST inhibition activity related to the WHO standard for IgE. 75% of the patients gave a larger weal area with an allergen concentration of 1:10(5) than with the next higher concentration, i.e. 1:10(4). Possible mechanisms whereby a larger skin weal is elicited with a lower concentration of allergen are discussed. This is not a rare finding and can be observed in patients undergoing routine skin testing in the clinic, even where extracts are diluted over a relatively narrow concentration range.
我们报告了对异位性个体皮肤进行鸭茅属花粉提取物系列稀释液点刺试验时发现的异常反应。每种花粉提取物均根据与WHO IgE标准相关的RAST抑制活性进行标准化。75%的患者对浓度为1:10(5)的变应原产生的风团面积大于下一个更高浓度即1:10(4)时产生的风团面积。文中讨论了用较低浓度变应原引发更大皮肤风团的可能机制。这并非罕见发现，在临床接受常规皮肤试验的患者中即可观察到，即使提取物在相对较窄的浓度范围内进行稀释。
