腹腔注射6-羟基多巴胺对大鼠脑内儿茶酚胺的更新率、水平及血浆皮质酮水平的影响。

The effects of intraperitoneal injection of 6-hydroxydopamine on the turnover and the levels of the brain catecholamines and the levels of plasma corticosterone in rats.

Kawa A, Kamisaki T, Ariyama T, Kawabata T, Maeda Y, Okamoto O, Kanehisa T

Clin Exp Pharmacol Physiol. 1979 Mar-Apr;6(2):123-8. doi: 10.1111/j.1440-1681.1979.tb00016.x.

Abstract

The effects of intraperitoneal injection of 6-hydroxydopamine (6-OHDA) on the levels and the turnover of brain catecholamines and the levels of plasma corticosterone were studied in rats. 2. Two weeks after intraperitoneal injection of 6-OHDA (150 mg/kg) a virtually complete disappearance of cardiac noradrenaline was observed. 3. An increment and an accelerated turnover of noradrenaline in the hypothalamus was observed 2 weeks after peripheral administration of 6-OHDA (150 mg/kg). 4. There was no change in the levels and the turnover of noradrenaline in the cortex of the rats so treated. 5. There was not change in the levels and the turnover of dopamine in either the hypothalamus or the cortex of the 6-OHDA-treated rats. 6. An increment and an accelerated turnover of hypothalamic noradrenaline were not associated with any change in plasma corticosterone.

摘要

研究了腹腔注射6-羟基多巴胺（6-OHDA）对大鼠脑儿茶酚胺水平及周转率和血浆皮质酮水平的影响。2. 腹腔注射6-OHDA（150mg/kg）两周后，观察到心脏去甲肾上腺素几乎完全消失。3. 外周给予6-OHDA（150mg/kg）两周后，观察到下丘脑去甲肾上腺素增加且周转率加快。4. 如此处理的大鼠皮质中去甲肾上腺素的水平及周转率无变化。5. 6-OHDA处理的大鼠下丘脑或皮质中多巴胺的水平及周转率均无变化。6. 下丘脑去甲肾上腺素的增加及周转率加快与血浆皮质酮的任何变化均无关。