Porter P, Noakes D E, Allen W D
Immunology. 1972 Sep;23(3):299-312.
Intestinal immunoglobulins have been examined in secretions obtained from Thiry-Vella loops prepared in the mid-jejunum of six calves. Free secretory component and 11S IgA were demonstrated. Immunofluorescent studies of intestinal tissue confirmed the presence of a secretory IgA system similar to that described in other species. However quantitative assays showed that IgA was not at any time the predominant immunoglobulin in intestinal secretions. IgM consistently exceeded the level of IgA by approximately two-fold and its localization in lymphoid cells of the lamina propria and crypt epithelial cells suggested that IgM may normally play an important role in local intestinal defence in the calf. IgG1 appeared in consistently low levels in intestinal secretions in spite of being the major serum immunoglobulin.
对取自六头小牛空肠中部制备的Thiry-Vella肠袢分泌物中的肠道免疫球蛋白进行了检测。检测到了游离分泌成分和11S IgA。肠道组织的免疫荧光研究证实存在类似于其他物种中所描述的分泌型IgA系统。然而,定量分析表明,IgA在任何时候都不是肠道分泌物中的主要免疫球蛋白。IgM的水平始终比IgA高出约两倍,并且其在固有层淋巴样细胞和隐窝上皮细胞中的定位表明,IgM可能在小牛的局部肠道防御中通常发挥重要作用。尽管IgG1是主要的血清免疫球蛋白,但在肠道分泌物中的水平一直很低。