Savilahti E
Clin Exp Immunol. 1972 Jul;11(3):415-25.
The numbers of immunoglobulin-containing cells in the mucosae of the small intestine and rectum were counted by a direct immunofluorescence technique in biopsy specimens from children. Immunoglobulins in the intestinal juice of the same patients were quantified by electroimmunodiffusion. In all biopsy specimens IgA-containing cells predominated. These cells were more numerous in the specimens from children over 2 years of age than in those of younger ones. The cells seemed to be fairly evenly distributed along the intestinal tract. The number of IgM-containing cells did not change with age in the group studied. In the intestinal juice the mean content of IgA was higher than that of the other immunoglobulins. More IgM and less IgA were found in the juice of infants under 2 years of age than in that of older children. The results suggest that quantitatively the IgA-producing system of the gut is not fully developed in infancy, whereas the reverse is true for the cells producing IgM.
采用直接免疫荧光技术，对取自儿童的活检标本中小肠和直肠黏膜中含免疫球蛋白的细胞进行计数。采用电免疫扩散法对同一患者肠液中的免疫球蛋白进行定量分析。在所有活检标本中，含IgA的细胞占主导地位。这些细胞在2岁以上儿童的标本中比在年龄较小儿童的标本中更多。这些细胞似乎沿肠道分布相当均匀。在所研究的组中，含IgM的细胞数量不随年龄变化。在肠液中，IgA的平均含量高于其他免疫球蛋白。与大龄儿童相比，2岁以下婴儿的肠液中发现更多的IgM和更少的IgA。结果表明，从数量上看，肠道产生IgA的系统在婴儿期并未完全发育，而产生IgM的细胞则相反。
