Epithelioma cuniculatum: verrucous carcinoma of the foot.

A patient with epithelioma cuniculatum, an unusual, highly keratinizing squamous cell neoplasm of the foot with locally aggressive behavior, is presented herein. Review of the literature reveals several similar cases that are reported under the names of epithelioma cuniculatum, papillomatosis cutis carcinoides, and verrucous carcinoma of the skin. The relationship of this neoplasm to other forms of verrucous carcinoma is noted. Lack of metastatic involvement indicates that a conservative surgical approach should be used, when possible, in the therapeutic management of this lesion.