Brinkmann W, Steigleder G K, Pullmann H
Z Hautkr. 1981 Jun 1;56(11):717-27.
We report about three cases of epithelioma cuniculatum. In two patients the tumour occurred at the auricle, in one patient at the forepart of the foot. One tumour at the ear was removed by local surgical excision, the other was treated by x-rays but without lasting success. In one patient amputation of the foot had been necessary because of intensive local invasion. The differentialdiagnosis especially at the sole of the foot must include viral warts and pseudocarcinomatous tumours as papillomatosis cutis carcinoides. The tumours on the ear could be misinterpreted as keratoacanthomas. Clinically the cauliflowerlike tumours empty on pressure foul smelling keratin. Histologically they show traits of a squamous carcinoma of low grade malignancy and an extreme keratinization beside the typical numerous anastomosing crypts similar to rabbit burrows.
我们报告了三例皮肤窦状癌。两名患者的肿瘤发生在耳廓，一名患者的肿瘤发生在足部前端。耳部的一个肿瘤通过局部手术切除，另一个接受了X线治疗但未取得持久成功。一名患者因局部侵袭严重而不得不进行足部截肢。特别是在足底的鉴别诊断必须包括病毒疣和类癌性皮肤乳头瘤病等假癌性肿瘤。耳部的肿瘤可能会被误诊为角化棘皮瘤。临床上，菜花状肿瘤受压时会排出有恶臭的角蛋白。组织学上，它们表现出低级别恶性鳞状癌的特征，除了典型的众多类似兔穴的吻合性隐窝外，还有极度角化。
