Opie L H, Lubbe W F
S Afr Med J. 1979 Nov 24;56(22):871-80.
Ventricular fibrillation is a major mechanism of sudden death. The cellular link between catecholamine activity and the development of serious ventricular arrhythmias may be in the formation of cyclic adenosine monophosphate (cAMP). Cyclic AMP and agents promoting cAMP accumulation allow development of slow responses which, especially in the presence of regional ischaemia, could develop into ventricular fibrillation. The role of beta-antagonist agents in the therapy of acute myocardial infarction is analysed in relation to the hypothesis linking cAMP and ventricular fibrillation. Reasons for the limited effectiveness of anti-arrhythmic therapy with beta-antagonist agents are given.
心室颤动是猝死的主要机制。儿茶酚胺活性与严重室性心律失常发生之间的细胞联系可能在于环磷酸腺苷（cAMP）的形成。环磷酸腺苷和促进cAMP积累的药物会引发缓慢反应，尤其是在存在局部缺血的情况下，这种缓慢反应可能发展为心室颤动。结合cAMP与心室颤动相关的假说，分析了β受体拮抗剂在急性心肌梗死治疗中的作用。给出了β受体拮抗剂抗心律失常治疗效果有限的原因。
