During the first phase of maturation in oocytes of Bufo bufo, after the growth phase but before ovulation, intracellular Na rises to 120 m-mole/l. cell water while K falls to 15 m-mole/l. cell water.2. At the same time, the ouabain-insensitive Na efflux and total Na influx both increase while the ouabain-sensitive Na efflux is unchanged.